MORPHOLOGICAL FEATURES OF POPLITEAL LYMPH NODES IN WHITE OUTBRED RATS WITH RHEUMATOID ARTHRITIS
Avezov Bakhrom Botirovich
Independent Researcher at Bukhara State Medical Institute named after Abu Ali Ibn Sino
https://orcid.org/0009-0004-4716-179X
Keywords: rheumatoid arthritis, peripheral lymph nodes, Alsian blue, histochemistry, morphometry, glycosaminoglycans, immune response, tissue remodeling.
Abstract
Abstract. The study investigates age-dependent histochemical and morphometric changes in peripheral lymph nodes of white outbred rats with experimental rheumatoid arthritis. Alsian blue staining revealed reactive-proliferative and reparative processes in young (3-month-old) rats, moderate compensatory activity in middle-aged (12-month-old) rats, and predominance of fibrotic and involutional changes in older (18-month-old) rats. Age-related accumulation of glycosaminoglycans in stroma, trabeculae, and sinus walls reflects chronic inflammation and tissue remodeling. The findings highlight dynamic structural and functional adaptations of lymph nodes in autoimmune pathology, providing insights into immunoregulatory mechanisms and potential therapeutic interventions.
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