Bolalarda OIV-infeksiyasida retrovirusga qarshi terapiyaga sodiqlik darajalarining immunologik ko‘rsatkichlarga ta’siri

Sadikov Xumoyun Mirzo Abdullayevich

Toshkent Davlat tibbiyot universiteti “Yuqumli va bolalar yuqumli kasalliklari” kafedrasi assistenti.

Keywords: OIV infeksiyasi, antiretrovirus terapiyasi, sodiqlik, CD4+ limfotsitlar, immunitet defitsiti, bolalar, immunologik tiklanish.

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Abstract

Tadqiqotda OIV-infeksiyali bolalarda antiretrovirus terapiyaga (ARVT) sodiqlik darajasining CD4+ limfotsitlar mutlaq ko‘rsatkichlariga ta’siri o‘rganildi. 695 bemor ma’lumotlari tahlil qilindi, median CD4+ ko‘rsatkichi 516,6±10,7 hujayra/ml bo‘lib, norma doirasida edi. Past sodiqlik guruhida normal daraja faqat 31,2% bemorlarda qayd etildi, 33,9%ida CD4+ 200 hujayradan past edi. O‘rta sodiqlikda normal daraja 49,1% (p<0,001), yuqori sodiqlikda esa 57,2%ga yetdi, 200 hujayradan past bo‘lganlar faqat 8% ni tashkil qildi (p<0,001). Natijalar ARVTga yuqori sodiqlik immunologik tiklanishni sezilarli darajada yaxshilashini ko‘rsatdi, ammo CD4+ darajasining to‘liq tiklanishi uchun uzoq muddatli kuzatuv zarurligi ta’kidlandi.

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