EFFECTIVENESS OF BLOODSTOP IN OPTIMIZING UTERINE SCAR REPAIR AFTER CESAREAN SECTION

Yuldashev S.A.

Independent researcher at the Termez branch of Tashkent State Medical University

Keywords: Keywords:cesarean section, BloodStop, myometrium, hemostatic agent, uterine scar, repair, ultrasound, morphological analysis, fibrosis, regeneration.

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Abstract

Abstract.
The aim of this study was to clinically and experimentally evaluate the effect of the BloodStop hemostatic agent on myometrial repair and uterine scar formation during cesarean section. Patients were divided into three groups: control, conventional hemostatic gels, and BloodStop. The results of ultrasound and morphological analyses showed that the use of BloodStop accelerated uterine involution, increased scar thickness and strength, and reduced myometrial thinning. In experimental studies, this agent provided optimal reparative processes characterized by minimal inflammatory reactions and low levels of fibrosis. The results obtained confirm the high efficacy of BloodStop and its importance in improving the functional recovery of the myometrium.

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References

1. Betrán, AP, Ye, J., Moller, AB, Zhang, J., Gülmezoglu, AM & Torloni, MR (2016). The increasing trend in caesarean section rates: global, regional and national estimates. PLOS ONE, 11(2), e0148343.

2. WHO (2021). WHO recommendations on non-clinical interventions to reduce unnecessary caesarean sections. Geneva: World Health Organization.

3. Silver, RM (2012). Implications of the first cesarean: perinatal and future reproductive health. Obstetrics & Gynecology, 119(2), pp. 329–340.

4. Tower, AM & Frishman, GN (2013). Cesarean scar defects: an underrecognized cause of abnormal uterine bleeding and other gynecologic complications. Journal of Minimally Invasive Gynecology, 20(5), pp. 562–572.

5. Heller, DS (2016). Pathology of cesarean section scars. Clinical Obstetrics and Gynecology, 59(3), pp. 495–503.

6. Di Spiezio Sardo, A., Calagna, G., Scognamiglio, M. et al. (2017). Prevention of cesarean scar defect: state of the art. European Journal of Obstetrics & Gynecology and Reproductive Biology, 219, pp. 19–23.

7. Chapron, C., Vannuccini, S., Santulli, P. et al. (2019). Diagnosing adenomyosis: an integrated clinical and imaging approach. Human Reproduction Update, 25(3), pp. 392–411.

8. Pereira, L., Reddy, UM & Berghella, V. (2015). Cesarean scar thickness and risk of uterine rupture. American Journal of Obstetrics and Gynecology, 212(2), pp. 232–240.

9. Ahmed, TAE, Dare, EV & Hincke, M. (2008). Fibrin: a versatile scaffold for tissue engineering applications. Tissue Engineering Part B, 14(2), pp. 199–215.

10. Balakrishnan, B. & Jayakrishnan, A. (2005). Self-cross-linking biopolymers as injectable in situ forming biodegradable scaffolds. Biomaterials, 26(18), pp. 3941–3951.