ONADAGI SURUNKALI BUYRAK YETISHMOVCHILIGI SHAROITIDA AVLODLAR NAYSIMON SUYAKLARINING POSTNATAL MORFOGENEZI

Mavlonov Otabek Murodillayevich

Urganch davlat tibbiyot instituti, mustaqil izlanuvchi

Baykabilova Gulruxsor Xayrullayevna

Xalqaro kimyo universiteti stomatologiya fakulteri talabasi

Keywords: surunkali buyrak yetishmovchiligi, ona organizmi, avlod, naysimon suyaklar, postnatal morfogenez, endoxondral suyaklanish, o‘sish plastinkasi, xondrotsit, osteogenez, mineralizatsiya.

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Abstract

Ushbu maqolada onadagi surunkali buyrak yetishmovchiligi sharoitida avlodlar naysimon suyaklarining tug‘ilgandan keyingi shakllanishini o‘rganishning morfologik va patogenetik asoslari tahlil qilinadi. Naysimon suyaklarning postnatal rivojlanishi o‘sish plastinkasidagi xondrotsitlar proliferatsiyasi va differensiyalanishi, endoxondral suyaklanish, suyak matriksining mineralizatsiyasi hamda suyak to‘qimasining qayta tuzilishi bilan bog‘liq holda yoritiladi. Onadagi buyrak faoliyati buzilishining avlod skeletiga ehtimoliy ta’siri mineral almashinuv, homila rivojlanishi va tug‘ilgandan keyingi o‘sish sharoitlari doirasida muhokama qilinadi. Mavjud dalillar onadagi buyrak kasalligi bilan bog‘liq perinatal xavflarni ko‘rsatsa-da, avlod naysimon suyaklaridagi muayyan postnatal o‘zgarishlarni ushbu holatning bevosita oqibati sifatida baholash uchun maxsus morfologik tadqiqotlar zarurligi asoslanadi. Mazkur yo‘nalishda gistologik, morfometrik, biokimyoviy va mikrostrukturaviy tekshiruvlarni birlashtirishning ilmiy ahamiyati ochib beriladi.

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