STRESS VA IMMUNITET: PSIXOLOGIK QIYINCHILIKLAR SALOMATLIKKA QANDAY TA’SIR QILADI?

Muhammadjonova Gulrux Farrux qizi

Qo’qon Universiteti Andijon filiali. Kunduzgi ta’lim psixologiya 2-bosqich talabasi.

Keywords: stress, immunitet, psixonevroimmunologiya, kortizol, yallig‘lanish, sitokinlar, surunkali stress, psixologik aralashuv

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Abstract

Ushbu maqolada stressning (o‘tkir va surunkali shakllari), psixologik qiyinchiliklar va immun tizim faoliyati o‘rtasidagi o‘zaro bog‘liqlik ilmiy manbalar asosida tahlil qilinadi. Stressga javoban gipotalamus–gipofiz–buyrak usti o‘qi hamda simpatik asab tizimi faollashishi natijasida kortizol va katexolaminlar ajralishi, yallig‘lanish sitokinlari muvozanati o‘zgarishi, shilliq qavatlar himoyasi kuzatilishi yoritiladi. Maqola doirasida stressning qisqa muddatda moslashuvchan himoya javoblarini kuchaytirishi mumkinligi, biroq uzoq davom etganda immun nazoratini susaytirishi, yallig‘lanishning surunkalashuvi orqali yurak-qon tomir, metabolik va infeksion kasalliklar xavfini oshirishi haqida xulosalar beriladi.

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References

1. Selye, H. The Stress of Life. New York, McGraw-Hill, 1956, 324 p.

2. Sapolsky, R. M.Why Zebras Don’t Get Ulcers: An Updated Guide to Stress, Stress-Related Diseases, and Coping. New York, Henry Holt and Company, 2004, 560 p.

3. Ader, R.Psychoneuroimmunology.Burlington, Elsevier Academic Press, 2007, 1200 p.

4. Lazarus, R. S.; Folkman, S.Stress, Appraisal, and Coping. New York, Springer Publishing Company, 1984, 456 p.

5. Cohen, S.; Tyrrell, D. A. J.; Smith, A. P. Psychological stress and susceptibility to the common cold. New England Journal of Medicine. Boston, Massachusetts Medical Society, 1991, Vol. 325, pp. 606–612.

6. Kiecolt-Glaser, J. K.; McGuire, L.; Robles, T. F.; Glaser, R. Emotions, morbidity, and mortality: new perspectives from psychoneuroimmunology. Annual Review of Psychology.Palo Alto, Annual Reviews, 2002, Vol. 53, pp. 83–107.

7. Glaser, R.; Kiecolt-Glaser, J. K.Handbook of Human Stress and Immunity.San Diego, Academic Press, 1994, 450 p.

8. Segerstrom, S. C.; Miller, G. E. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychological Bulletin. Washington, American Psychological Association, 2004, Vol. 130, No. 4, pp. 601–630.

9. Irwin, M. R.; Opp, M. R. Sleep health: reciprocal regulation of sleep and innate immunity. Neuropsychopharmacology. New York, Nature Publishing Group, 2017, Vol. 42, pp. 129–155.

10. Dhabhar, F. S. Effects of stress on immune function: the good, the bad, and the beautiful. Immunologic Research.Totowa, Humana Press, 2014, Vol. 58, pp. 193–210.